HORDB

ID: hor005233
Uniprot ID: Q29119
Protein name: Islet amyloid polypeptide
Gene name: IAPP
Organism: Sus scrofa (Pig)
Family: Calcitonin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q29119-F1.pdb

hor005233_AF2.pdb

hor005233_ESM.pdb

Mass:	401903	Formula:	C147H238N46O47S2
Absent amino acids:	EWY	Common amino acids:	NT
pI:	9.83	Basic residues:	4
Polar residues:	14	Hydrophobic residues:	10
Hydrophobicity:	-28.75	Boman Index:	-6073
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	67.19
Instability Index:	3351.25	Extinction Coefficient cystines:	0
Absorbance 280nm:	0